Archive for Bioinformatics

Bioinformatics video lectures

Posted in Bioinformatics with tags , on November 17, 2006 by wsjoung

There is really great group which is providing online lectures in bioinformatics

“The S* group of teaching institutions have formed a global alliance to provide a global, unified bioinformatics learning environment (GLOBULE) made up of modular courses in the disciplines of genomics, bioinformatics, and medical informatics.”

S* Alliance

Comparative Protein Modeling

Posted in Bioinformatics with tags , , on November 17, 2006 by wsjoung

Once we figure out the protein sequence, then how we can figure out its 3D structure?
There are two kinds of methods. Physical and empirical methods. The physical prediction methods are based on interactions between atoms and include molecular dynamics and energy minimization, whereas the empirical methods depend on the protein structures that have been already determined by experiments.
A comparative protein modeling method designed to find the most probable structure for a sequence given its alignment with related structures. 3D model is obtained by optimally satisfying spatial restraints derived from the alignment and expressed as probability density functions for the features restrained.

Evolution and Physics in comparative protein structure modeling.pdf
Comparative_Protein_Modeling.pdf